Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the (2A)-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-B Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Yiheng;Wu, Shan;Yu, Xiaofang;Zhou, Shaoli;Ge, Mian;...

通讯作者：

Chi, Xinjin;Cai, Jun

作者机构：

[Chi, XJ; Cai, Jun; Zhou, Shaoli; Chi, Xinjin; Wu, Shan; Wang, Yiheng; Ge, Mian] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China.

[Wang, Yiheng] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Peoples R China.

[Yu, Xiaofang] Fujian Prov Hosp, Dept Anesthesiol, Fuzhou 350000, Peoples R China.

通讯机构：

[Chi, XJ; Cai, J] S

Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China.

语种：

英文

关键词：

TLR4/NF-kappaB;dexmedetomidine;ischemia-reperfusion injury;liver transplantation;alpha2A-adrenoceptor subtype

期刊：

International Journal of Molecular Sciences

ISSN：

1422-0067

年：

2016

卷：

期：

DOI：

10.3390/ijms17070995

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471892]; Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2014A030313199]; Science and Technology Project Foundation of Guangdong Province, China [2008B030301053, 2013B021800181]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signaling plays a dominant role in the pathogenesis of liver ischemia-reperfusion (IR) injury. Dexmedetomidine (Dex) protects the liver against IR injury via alpha(2)-adrenoceptor activation, but the contribution of TLR4 signaling remains unknown. The authors aimed to examine whether pretreatment with Dex produces hepatic protection and investigate the influence of Dex on TLR4/NF-kappaB signaling. Dex was given via intraperitoneal injection 30 min prior to orthotopic autologous liver transplantation (OALT) in rats, and three alpha(...

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Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the (2A)-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-B Pathway

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