[Zeng, Si-yu; Lu, Hui-qin] Guangdong Second Prov Gen Hosp, Dept Drug Clin Trial, Guangzhou, Guangdong, Peoples R China

[Yang, Li; Qin, Xu-ping] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang, Hunan, Peoples R China

[Yan, Qiu-jiang] Guangzhou Med Univ, Dept Cardiac & Thorac Surg, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

[Gao, Ling] Guangdong Second Prov Gen Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China

[Zeng, Si-yu] G

[Qin, Xu-ping] U

Guangdong Second Prov Gen Hosp, Dept Drug Clin Trial, Guangzhou, Guangdong, Peoples R China. Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang, Hunan, Peoples R China.

angiotensin II;atrial natriuretic factor;brain natriuretic peptide;collagen type 1;collagen type 3;glyceraldehyde 3 phosphate dehydrogenase;hydrogen peroxide;mitogen activated protein kinase 1;mitogen activated protein kinase 3;reactive oxygen metabolite;reduced nicotinamide adenine dinucleotide phosphate oxidase 4;rutaecarpine;superoxide dismutase;tumor necrosis factor;tumor necrosis factor alpha converting enzyme;angiotensin II;indole alkaloid;quinazoline derivative;reactive oxygen metabolite;reduced nicotinamide adenine dinucleotide phosphate oxidase 4;rutaecarpine;tumor necrosis factor alpha converting enzyme;animal cell;animal cell culture;animal experiment;animal model;animal tissue;aortic constriction;arterial pressure;Article;blood pressure measurement;controlled study;drug megadose;enzyme activity;enzyme linked immunosorbent assay;experimental hypertension;fractional shortening;gene expression;heart ejection fraction;heart left ventricle pressure;heart rate;heart ventricle hypertrophy;heart ventricle overload;heart ventricle size;hemodynamic parameters;histology;immunohistochemistry;low drug dose;male;MAPK signaling;nonhuman;priority journal;protein expression;rat;real time polymerase chain reaction;RNA isolation;transthoracic echocardiography;upregulation;Western blotting;abdominal aorta;animal;cardiac muscle cell;cardiomegaly;complication;Dahl rat;drug effect;gene expression regulation;genetics;human;hypertension;MAPK signaling;metabolism;pathology;stenosis, occlusion and obstruction;ADAM17 Protein;Angiotensin II;Animals;Aorta, Abdominal;Cardiomegaly;Constriction, Pathologic;Gene Expression Regulation;Humans;Hypertension;Indole Alkaloids;MAP Kinase Signaling System;Myocytes, Cardiac;NADPH Oxidase 4;Quinazolines;Rats;Rats, Inbred Dahl;Reactive Oxygen Species

药学与生物科学学院