Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway

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成果类型：

期刊论文

作者：

Zeng, Si-yu*;Yang, Li;Lu, Hui-qin;Yan, Qiu-jiang;Gao, Ling;...

通讯作者：

Zeng, Si-yu;Qin, Xu-ping

作者机构：

[Zeng, Si-yu; Lu, Hui-qin] Guangdong Second Prov Gen Hosp, Dept Drug Clin Trial, Guangzhou, Guangdong, Peoples R China

[Yang, Li; Qin, Xu-ping] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang, Hunan, Peoples R China

[Yan, Qiu-jiang] Guangzhou Med Univ, Dept Cardiac & Thorac Surg, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

[Gao, Ling] Guangdong Second Prov Gen Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China

通讯机构：

[Zeng, Si-yu] G

[Qin, Xu-ping] U

Guangdong Second Prov Gen Hosp, Dept Drug Clin Trial, Guangzhou, Guangdong, Peoples R China. Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

NADPH oxidase 4;a disintegrin and metalloproteinase-17;extracellular signal-regulated kinase (1/2);hypertensive cardiac hypertrophy;rutaecarpine

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2019

卷：

期：

页码：

4196-4207

DOI：

10.1111/jcmm.14308

基金类别：

Science and Technology Planning Project of Guangdong Province [2016A020226005]; Nature Scientific Foundation of Guangdong Second Provincial General Hospital [YQ2015-008]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2015A030310076]

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Rutaecarpine attenuates hypertensive cardiac hypertrophy in the rats with abdominal artery constriction (AAC); however, its mechanism of action remains largely unknown. Our previous study indicated that NADPH oxidase 4 (Nox4) promotes angiotensin II (Ang II)-induced cardiac hypertrophy through the pathway between reactive oxygen species (ROS) and a disintegrin and metalloproteinase-17 (ADAM17) in primary cardiomyocytes. This research aimed to determine whether the Nox4-ROS-ADAM17 pathway is involved in the protective action of rutaecarpine against hypertensive cardiac hypertrophy. AAC-induced ...

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Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway

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