Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ying, Shangyun;He, Jun;Yu, Minjun;Zhang, Yukuai;Deng, Suhong;...

通讯作者：

Hu, Sihai

作者机构：

[Deng, Suhong; Hu, Sihai; Zhang, Lusi; Zhang, Yukuai; Xie, Meihua; Ying, Shangyun; He, Jun; Yu, Minjun] Univ South China, Pathogen Biol Inst, Coll Basic Med, Hengyang 421001, Hunan, Peoples R China.

[He, Jun] Univ South China, Dept Clin Lab, Nanhua Affiliated Hosp, Hengyang 421001, Hunan, Peoples R China.

[Hu, Sihai] Univ South China, Pathogen Biol Inst, Coll Basic Med, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Hu, Sihai] U

Univ South China, Pathogen Biol Inst, Coll Basic Med, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Neisseria surface protein A;recombinant protein;vaccine candidate;protection;Neisseria meningitides serogroup B

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2014

卷：

期：

页码：

1619-1625

DOI：

10.3892/mmr.2014.2325

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172890]; Construct Program of the Key Discipline in Hunan Province; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5-2012-312]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Neisseria meningitidis is the pathogen of epidemic encephalomyelitis and is responsible for permanent damage to the brain and nervous system. In the present study, the prokaryotic expression vector pGEX-6p-1/neisseria surface protein A (NspA) was constructed and the immune protective effect was investigated with the purified recombinant rNspA. Female BALB/c mice were immunized by intraperitoneal inoculation of rNspA, glutathione S-transferase (GST) or phosphate-buffered saline (PBS). The protection experiment in mice demonstrated that the protection rate of the rNspA group was 85% against the ...

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Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B

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