In this paper, the gamma ray shielding of depleted uranium is verified by experiment and simulation. A nuclear power pressurized water reactor shielding model is constructed, and the simulation distribution of neutron energy spectrum in the shielding layer was consistent with that in practice. The comprehensive shielding performance of depleted uranium in different positions of neutron and gamma mixed radiation field were simulated by the Monte Carlo simulation method and the fuel consumption calculation program, and compared with that of the l...