期刊论文

Xie, HT

英文

Biochemical Pharmacology

0006-2952

2023

213

115628

10.1016/j.bcp.2023.115628

This work was supported by Natural Science Foundation of Hunan Province, China (NO.2019JJ80035 and NO.2023JJ60052), and University of South China Innovation Foundation For Postgraduate (223YXC027) and Hunan Provincial Innovation Foundation for Postgraduate (CX20221009). CRediT authorship contribution statement Jie Luo: Conceptualization, Software, Visualization, Writing – original draft, Writing – review & editing. Jingsong Cao: Writing – review & editing, Supervision, acquisition. Cong Chen: Project administration, acquisition. Haitao Xie: Conceptualization, Supervision, Project administration, acquisition, Writing – review & editing.

本校为第一且通讯机构

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely distributed from archaea to eukaryotes and acts as a posttranscriptional chemical modification of RNA, contributing to the correct reading of specific nucleotide sequences during translation, stabilising mRNA and improving transcription efficiency. Yeast Kre33 and human NAT10, the only known authors of ac4C, modify tRNA with the help of the Tan1/THUMPD1 adapter to stabilise its structure. Currently, the mRNA for N4-acetylcytidine (ac4C), catalysed by NAT10 (N-acetyltransferase 10), has been implicated in a vari...