期刊论文

中文

解剖学报

0529-1356

2023

54

1

42-49

10.16098/j.issn.0529-1356.2023.01.006

湖南省自然科学基金(2018JJ3429)。

本校为第一机构

目的探讨慢性束缚应激(CRS)对小鼠海马星形胶质细胞表型转换及抑郁样行为的影响。方法48只雄性C57BL/6小鼠随机分为对照组(control)、模型组(CRS)、氟西汀(FLX)药物干预组(CRS+FLX),每组各16...展开更多 目的探讨慢性束缚应激(CRS)对小鼠海马星形胶质细胞表型转换及抑郁样行为的影响。方法48只雄性C57BL/6小鼠随机分为对照组(control)、模型组(CRS)、氟西汀(FLX)药物干预组(CRS+FLX),每组各16只。慢性束缚应激3周建立抑郁小鼠模型,应激的第8天至第21天,CRS+FLX组于应激前30 min腹腔注射FLX(10 mg/kg),control组及CRS组注射等体积生理盐水。采用旷场实验以及糖水偏好实验检测各组小鼠行为变化;采...

Objective To explore the effect of chronic restraint stress(CRS)on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice.Methods Forty eight male C57BL/6 mice were randomly divided into control groups(control),model groups(CRS)and fluo...MORE Objective To explore the effect of chronic restraint stress(CRS)on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice.Methods Forty eight male C57BL/6 mice were randomly divided into control groups(control),model groups(CRS)and fluoxetine(FLX)drug intervention groups(CRS+FLX),16 for ...