期刊论文

Chen, N

英文

Frontiers in Microbiology

1664-302X

2025

16

1619101

10.3389/fmicb.2025.1619101

The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the Natural Science Foundation of Hunan Province, China (grant numbers 2022JJ30524, 2024JJ9389, 2023JJ60046, and 2025JJ81014) and the Scientific Research Project of the Hunan Provincial Health Committee (grant number 20230954).

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Outer membrane vesicles (OMVs) derived from Pseudomonas aeruginosa drive inflammation by metabolically reprogramming macrophages to favor aerobic glycolysis. This study shows that OMVs trigger this metabolic shift via Toll-like receptors 2 and 4 (TLR2/4)-dependent activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. OMV-stimulated macrophages exhibited increased glucose uptake, lactate production, and expression of key glycolytic enzymes, resulting in a higher extracellular acidification rate and a lower oxygen consumption rate. Inhibition of the PI3K/Ak...