A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qiu, Jin-Mei;Qin, Chang-Feng;Wu, Shen-Gen;Ji, Tong-Ying;Tang, Guo-Tao;...

通讯作者：

Cao, Xuan;Xie, Zhi-Zhong

作者机构：

[Xie, Zhi-Zhong; Cao, Xuan; Xie, ZZ; Lei, Xiao-Yong; Tang, Guo-Tao; Qin, Chang-Feng; Ji, Tong-Ying; Qiu, Jin-Mei; Wu, Shen-Gen] Univ South China, Hunan Prov Key Lab Tumour Microenvironm Respons D, 28 Chang Sheng Rd, Hengyang City 421001, Hunan, Peoples R China.

[Xie, Zhi-Zhong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

通讯机构：

[Cao, X; Xie, ZZ] U

Univ South China, Hunan Prov Key Lab Tumour Microenvironm Respons D, 28 Chang Sheng Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

antioxidant;free radical scavenging ability;resveratrol;salvianolic acid A

期刊：

Drug Development Research

ISSN：

0272-4391

年：

2021

卷：

期：

页码：

108-114

DOI：

10.1002/ddr.21734

基金类别：

Education Department General Project of Hunan Province, Grant/Award Number: 09C830; Undergraduate Training Program for Innovation and Entrepreneurship of Hunan Province, Grant/Award Number: 2324; Natural Science Foundation of Hunan Province, Grant/Award Number: 2019JJ40251; Hunan Provincial Innovation Foundation for Postgraduate, Grant/Award Number: CX20190748 Funding information

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

AbstractE‐DRS is a novel salvianolic acid A (SAA) analog, which was synthesized from resveratrol (RES) and methyldopate. Its structure is similar to that of SAA, but the 3′,4′‐dihydroxy‐trans‐stilbene group and the ester structure in SAA were replaced by the RES structure and an amine group, respectively. E‐DRS scavenged free oxygen radicals effectively, including superoxide anion (ascorbic acid > E‐DRS > SAA ≥ rutin > RES) and DPPH radical (rutin > E‐DRS ≥ ascorbic acid > SAA > RES), and exhibited powerful tota...

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A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo

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