期刊论文

中文

中国医师杂志

1008-1372

2018

20

4

635-638

10.3760/cma.j.issn.1008-1372.2018.04.050

本校为第一机构

肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)是肿瘤坏死因子超家族的新成员之一。TWEAK通过细胞间的相互作用或旁分泌方式与其受体成纤维细胞生长因子诱导早期反应蛋白14(Fn14)结合,调节细胞的增殖、分化、迁移、凋亡和炎症等多种活动。TWEAK/Fn14信号通路在肺损伤、哮喘以及肺癌等肺部疾病发生发展过程中的作用日益受到关注。

Tumor necrosis factor-like attenuated apoptosis inducer （TWEAK） is a new member of the tumor necrosis factor super family. TWEAK regulates cellular proliferation, differentiation, migration, apoptosis and inflammation by binding its receptor, fibroblast growth factor-inducible 14 （Fn14） , through the interaction between cells or in a paracrine fashion. The role of TWEAK / Fn14 signaling pathway in the development of lung diseases such as lung injury...