期刊论文

Observation of oxidative stress condition and macular edema in patients of early diabetic retinopathy treated by probucol

中文

中国医师杂志

1008-1372

2011

13

2

154-157

10.3760/cma.j.issn.1008-1372.2011.02.004

湖南省卫生厅课题（C2008-011）； 湖南省科技计划项目（2009FJ3033）； 诺美国际基金资助项目；

本校为第一机构

目的 研究普罗布考对非增殖型糖尿病变视网膜病变（NPDR）患者血脂、血清总抗氧化能力（TAOC）、丙二醛（MDA）浓度、超氧化物歧化酶（SOD）水平及黄斑水肿的影响,为普罗布考防治早期DR提供临床依据.方法 纳入66例伴NPDR的2型糖尿病患者127眼,随机分为对照组和治疗组：对照组进行强化降血糖、血压治疗,治疗组在强化治疗基础上加用普罗布考0.375 g,2次/d,口服,总疗程为12月.治疗前后两组患者均进行了血脂、氧化应激指标及眼底荧光血管造影检查.结果 共有62例120眼完成研究,普罗布考组患者总胆固醇（TC）[（3.6±0.58）mmol/L VS（4.71±0.61）mmol/L,t=7.65,P＜0.01]、甘油三酯（TG）[（1.07±0....

Objective To study the influence of probucol on the diabetic mellitus patients with non-proliferative diabetic retinopathy （NPDR） about blood lipids,serum level of the total antioxidant capacity （TAOC）,malondialdehyde （MDA）,superoxide dismutase （SOD） and macular edema,so as to provide clinical basis for the prevention and treatment of early DR by probucol.Methods 66 type 2 diabetes patients with 127 NPDR eyes were included.Patients were random divided into control and treatment groups,the control group was treated by intensive therapy o...