期刊论文

中文

中国医师杂志

1008-1372

2010

12

9

1166-1170

10.3760/cma.j.issn.1008-1372.2010.09.004

湖南省医药卫生科研课题（C2008-015）；

本校为第一机构

目的 去甲二氢愈创木酸（nordihydroguaiaretic acid,NDGA）对多种肿瘤细胞具有抑制增殖和诱导凋亡作用,本文主要研究去甲二氢愈创木酸对大鼠慢性萎缩性胃炎（CAG）的预防作用,初步探讨其作用机制.方法 建立Wistar大鼠慢性萎缩性胃炎模型,将72只Wistar大鼠采用随机分组法平分为6组：正常组、模型组、三种不同剂量去甲二氢愈创木酸干预组和对照组.喂养24周后,处死大鼠,观察大鼠大体标本、胃黏膜HE染色后病理组织学改变,并采用免疫组化检测各组大鼠胃黏膜组织的5-脂氧合酶（5-LOX）、多肿瘤抑制基因（P16）蛋白的表达情况.结果 模型组萎缩性胃炎发生率较正常组明显高（77.8%vs 0%,P＜0.05）,说明造...

Objective To study the preventive effect of lipoxygenase inhibitor nordihydroguaiaretic acid （NDGA） on chronic atrophic gastritis （CAG）. Methods To construct CAG rat model, 72 male rats were randomly divided into 6 groups, including normal group, CAG model group, NDGA group with different dose and positive groups （folacin）. After feeding for 24 weeks, all rats were executed, their stomach mucous membrane was picked out and stained with H.E. The expression of 5-LOX and P16 protein in mucous membrane epithelia cells were detected by immunoh...