期刊论文

The effect of suramin in combination with adriamycin on HIF-1α and VEGF expressions in mice transplanted with lung adenocarcinoma

中文

中国医师杂志

1008-1372

2006

8

11

1462-1464

10.3760/cma.j.issn.1008-1372.2006.11.009

湖南省卫生厅科研课题资助项目（C2005033）；

本校为其他机构

目的研究苏拉明联合阿霉素对肺腺癌小鼠移植瘤组织中缺氧诱导因子-1α（H IF-1α）和血管内皮细胞生长因子（VEGF）表达的调控及对移植瘤增殖的影响。方法复制肺腺癌LA795细胞的T739小鼠异体移植瘤模型。40只实验小鼠皮下移植处均成瘤,接种后4d随机分为4组,10只/组。对照组:生理盐水0.2 m l/只,于接种后第4天开始腹腔注射,1次/d,共16次;阿霉素组:阿霉素（2 mg.kg-1.d-1）溶于0.2 m l生理盐水中,于接种后第4,11,18天各腹腔注射1次;苏拉明组:苏拉明（10 mg.kg-1.d-1）溶于0.2 m l生理盐水中,余同对照组;联合组（阿霉素+苏拉明）:按阿霉素组和苏拉明组用药。肿瘤接种后24 d,测量小鼠皮下肿瘤最大长...

Objective To study the regulation of Suramin in combination with Adriamyein and its effect on the HIF-1α and VEGF expressions in mice transplanted with lung adenocareinoma, Methods LA795 cells were subcutaneously inoeulated into the mammary fatty pad of T739 mice to establish the lung adenocareinoma model. After the treatment, 40 experimental mice were randomized into four groups （ten in each group）. Control group： every mouse was injected into abdominal cavity with 0. 2mt 0. 9% sodium chloride aqua everyday, 16 times total. Adriamycin grou...