Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform

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成果类型：

期刊论文

作者：

Wang, Futing;Zhang, Chunxiao;Deng, Suping;Jiang, Yifei;Zhang, Penghui;...

通讯作者：

Xiang, Li;Cai, R;Yang, HF

作者机构：

[Wang, Futing; Xiang, Li; Cai, Ren; Zhang, Chunxiao; Lyu, Yifan; Xiang, L; Tan, Weihong] Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensin, Changsha 410082, Peoples R China.

[Yang, Hongfen; Yang, HF; Deng, Suping] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Zhang, Penghui; Jiang, Yifei; Tan, Weihong] Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China.

通讯机构：

[Yang, HF ] U

[Xiang, L; Cai, R ] H

Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensin, Changsha 410082, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Double-response 3D DNA nanomachine;High efficiency;Hybridization chain reactions;Laser-scribed graphene;Real-time monitor

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2024

卷：

252

页码：

116149

DOI：

10.1016/j.bios.2024.116149

基金类别：

CRediT authorship contribution statement Futing Wang: Investigation, Data curation. Chunxiao Zhang: Data curation. Suping Deng: Formal analysis. Yifei Jiang: Formal analysis. Penghui Zhang: Formal analysis. Hongfen Yang: Writing – review & editing, Supervision, Investigation, Formal analysis, Conceptualization. Li Xiang: Writing – review & editing, Supervision, Formal analysis. Yifan Lyu: Formal analysis. Ren Cai: Writing – review & editing, Writing – original draft, Supervision, Investigation, acquisition, Conceptualization.

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

The microRNA-21 is closely related to chromatin remodeling and epigenetic regulation. In this work, an efficient double-response 3D DNA nanomachine (DRDN) was assembled by co-immobilizing two different lengths of hairpin DNA on the surface of gold nanoparticles (AuNPs) to capture microRNA-21 (miRNA-21), recycle miRNA-21, and trigger hybridization chain reactions (HCR). This work reports the fabrication of a laser-scribed graphene (LSG) electrode with excellent flexibility and electrical conductivity by laser-scribing commercial polyimide films ...

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Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform

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