期刊论文

中文

中华器官移植杂志

0254-1785

2011

32

3

168-171

10.3760/cma.j.issn.0254-1785.2011.03.011

本校为第一机构

目的研究大鼠移植心脏冠状血管组织中整合素ανβ3 的表达情况及西罗莫司(SRL)对其的影响,探讨SRL 预防移植心脏血管病变的可能机制.方法一实验共分4组,每组受者8只,建立大鼠腹腔异位心脏移植模型:(1)同系移植组:供、受者均为Wistar大鼠;(2)同种异体移植环孢素 A组(CsA组):以Wistar大鼠作为供者,SD大鼠作为受者,移植后受者皮下注射CsA 10 mg·kg~(-1)·d~(-1);(3)同种异体移植SRL组(SRL组):以Wistar大鼠作为供者,SD大鼠作为受者,移植后受者用SRL 1.25 mg·kg~(-1)·d~(-1)灌胃;(4)对照组:取未经任何处理的Wistar大鼠作为正常对照.移植后60 d,取移植心脏组织,行Van Gieson染色观察移植心脏血管病...

Objective To investigate the effect of sirolimus (SRL) on the expression of integrin ανβ3 mRNA in vascular smooth muscle cells of cardiac allografts in rats, and the possible mechanism of SRL in the prevention of cardiac allograft vasculopathy. Methods Heterotopic heart transplantation models were established. Hearts from Wistar rats were heterotopically transplanted to SD rats (allograft) or Wistar rats (isograft). All rats were randomly divided into four groups:SRL group, SRL 1.25 mg/kg every day,oral intubation after cardiac transplantati...