Selection and identification of novel peptides specifically targeting human cervical cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xiaomin;Peng, Jingwen;He, Jie;Li, Qiaoran;Zhou, Jianbin;...

通讯作者：

Liang, Xiaoqiu;Tang, Shengsong

作者机构：

[He, Jie; Li, Qiaoran; Liang, Xiaoqiu; Liu, Xiaomin; Peng, Jingwen] Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[He, Jie; Li, Qiaoran; Liang, Xiaoqiu; Liu, Xiaomin; Peng, Jingwen] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Jianbin] Univ South China, Dept Gynecol & Obstet, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shengsong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shengsong] Hunan Univ Med, Biomed Res Ctr, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Liang, Xiaoqiu; Tang, Shengsong] U

[Tang, Shengsong] H

Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Peptides;Tumor targeting;Cervical cancer;Phage display

期刊：

Amino Acids

ISSN：

0939-4451

年：

2018

卷：

期：

页码：

577-592

DOI：

10.1007/s00726-018-2539-1

基金类别：

aVs normal cervical tissues, χ2 = 25.755, P < 0.01 bVs normal cervical tissues, χ2 = 0.000, P > 0.05 cVs normal cervical tissues, χ2 = 0.000, P > 0.05 dVs normal cervical tissues, χ2 = 37.723, P < 0.01 Acknowledgements We would like to express our gratitude to Dr. Tang and Dr. Liang, who provided valuable guidance in each stage of our paper writing. We would also like to show our appreciation to all individuals who contributed to this paper. This study was supported by the National Natural Science Foundation of China (Grant no. 81472449 and 81101988), the Hunan Provincial Education Department Foundation of China (Grant no. 11C1091), and the Hengyang Industry University Research Project in Hunan Province of China (Grant no. 2015kc53). The study was performed using equipment purchased with funding from the construction program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Cervical cancer is the second most commonly diagnosed cancer and the third leading cause of cancer deaths among females in underdeveloped countries. This study aimed to identify several novel cervical cancer-specific targeting peptides (CSPs) to provide new methods for the effective diagnosis and treatment of cervical cancer. Peptide library screening in vivo was performed on human cervical cancer xenografts with Ph.D.™-12 and C7C phage display peptide libraries. Two specific peptide sequences (GDALFSVPLEVY and KQNLAEG), which were enriched in...

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Selection and identification of novel peptides specifically targeting human cervical cancer

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