ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zu, Xu-Yu;Zhang, Qing-Hai;Liu, Jiang-Hua;Cao, Ren-Xian;Zhong, Jing;...

通讯作者：

Pizzorno, Giuseppe

作者机构：

[Zhong, Jing; Quan, Zhi-Hua; Zhang, Qing-Hai; Cao, Ren-Xian; Zu, Xu-Yu; Liu, Jiang-Hua] Univ S China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Pizzorno, Giuseppe] Desert Res Inst Summerlin, Human Hlth & Environm Program, Las Vegas, NV 89135 USA.

[Yi, Guang-Hui] Univ S China, Sch Med, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Pizzorno, Giuseppe] Desert Res Inst Summerlin, Human Hlth & Environm Program, 10530 Discovery Dr, Las Vegas, NV 89135 USA.

通讯机构：

[Pizzorno, Giuseppe] D

Desert Res Inst Summerlin, Human Hlth & Environm Program, 10530 Discovery Dr, Las Vegas, NV 89135 USA.

语种：

英文

关键词：

ACL inhibitors;ATP citrate lyase;Hydroxycitrate;Non-hydroxycitrate Citric Acid Analogues;Posttranslational regulation;Transcriptional regulation;cancer therapy;citrate;lipogenesis;small chemicals

期刊：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY

ISSN：

1574-8928

年：

2012

卷：

期：

页码：

154-167

DOI：

10.2174/157489212799972954

基金类别：

Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [11JJ4068]; Medical Scientific Research Foundation of Hunan Province, China [B2010-045]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

ATP citrate lyase (ACL or ACLY) is an extra-mitochondrial enzyme widely distributed in various human and animal tissues. ACL links glucose and lipid metabolism by catalyzing the formation of acetyl-CoA and oxaloacetate from citrate produced by glycolysis in the presence of ATP and CoA. ACL is aberrantly expressed in many immortalized cells and tumors, such as breast, liver, colon, lung and prostate cancers, and is correlated reversely with tumor stage and differentiation, serving as a negative prognostic marker. ACL is an upstream enzyme of the long chain fatty acid synthesis, providing acetyl...

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