The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

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成果类型：

期刊论文

作者：

Yang, Kai*;Wang, Xi;Pan, Hanyu;Wang, Xinqing;Hu, Yunhan;...

通讯作者：

Yang, Kai;Sun, TL

作者机构：

[Zhao, Xinyue; Sun, TL; Pan, Hanyu; Sun, Taolei; Yang, Kai; Yang, K; Hu, Yunhan; Wang, Xi] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan, Peoples R China.

[Sun, TL; Sun, Taolei; Yang, Kai; Yang, K] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Hubei Key Lab Nanomed Neurodegenerat Dis, Wuhan, Peoples R China.

[Wang, Xinqing] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang, Peoples R China.

[Yao, Yihe] Wuhan Univ Technol, Inst WUT AMU, Wuhan, Peoples R China.

[Sun, TL; Sun, Taolei] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan, Peoples R China.

通讯机构：

[Sun, TL ; Yang, K] W

Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan, Peoples R China.

Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Hubei Key Lab Nanomed Neurodegenerat Dis, Wuhan, Peoples R China.

Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan, Peoples R China.

语种：

英文

关键词：

AIM2;Alzheimer’s disease;Parkinson’s disease;inflammasome;neurodegenerative disease

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2024

卷：

页码：

1441385

DOI：

10.3389/fimmu.2024.1441385

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China to TS (51873168).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate inflammasome assembly. Additionally, we explore the diverse functions of AIM2 in different cells. Insights into AIM2-mediated neuroinflammation provide a foundation for investigating novel therapeutic strategies targeting AIM2 signaling pathways. Furthermore, we present a comprehensive review of the roles of AIM2 in neurodegenerative diseases, i...

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The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

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