期刊论文

Tang, Chao-ke

英文

DNA AND CELL BIOLOGY

1044-5498

2013

32

7

348-358

10.1089/dna.2012.1940

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070220, 81170278]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province [2008-244]; Scientific Research Fund of Hunan Provincial Education Department, ChinaHunan Provincial Education Department [12C0339]

本校为第一且通讯机构

Aim: Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function. Results: The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional mechanisms. ABCA1 mRNA clearance is induced by several microRNAs that result in translational repression and reduction of ABCA1 protein expression. Intracellular ABCA1 trafficking is enhance...