Polymorphisms in PI3K/AKT genes and gene-smoking interaction are associated with susceptibility to tuberculosis

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成果类型：

期刊论文

作者：

Wu, Chunli;Liu, Huixia;Lin, Ying;An, Rongjing;Wang, Mian;...

通讯作者：

Deng, Jing;Chen, MS

作者机构：

[Deng, Jing; Liu, Huixia; Tan, Hongzhuan; Wu, Chunli; Chen, Mengshi; Lin, Ying; Chen, Lizhang; An, Rongjing] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, 238 Shangmayuanling Lane, Changsha, Hunan, Peoples R China.

[Wang, Mian] Univ South China, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hengyang, Hunan, Peoples R China.

[Zhong, Hua] Cent South Univ, Xiangya Hosp, Dept Cardiol, Changsha, Hunan, Peoples R China.

[Yi, Hengzhong; Wang, Qiaozhi] Hunan Prov Chest Hosp, Changsha, Hunan, Peoples R China.

通讯机构：

[Chen, MS ; Deng, J] C

Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, 238 Shangmayuanling Lane, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Tuberculosis;PI3KR1;AKT1;Smoking;Single nucleotide polymorphism (SNP)

期刊：

Annals of Human Biology

ISSN：

0301-4460

年：

2023

卷：

期：

页码：

472-479

DOI：

10.1080/03014460.2023.2288008

基金类别：

Mega Project of Research on the Prevention and Control of HIV/AIDS, Viral Hepatitis Infectious Diseases; Mega Project of Research on the Prevention and Control of HIV/AIDS, Viral Hepatitis Infectious Diseases [2018ZX10302302001008]; National Natural Science Foundation of China [81803298, 81800275]; Hunan Provincial Natural Science Foundation of China [2020JJ4762, 2020JJ5955]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Background: Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) are involved in the clearance of Mycobacterium tuberculosis (MTB) by macrophages.Aim: This study aimed to investigate the effects of polymorphisms in the PI3K/AKT genes and the gene-smoking interaction on susceptibility to TB.Methods: This case-control study used stratified sampling to randomly select 503 TB patients and 494 control subjects. Logistic regression analysis was used to determine the association between the polymorphisms and TB. Simultaneously, the marginal structure linear dominance model was used to esti...

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Polymorphisms in PI3K/AKT genes and gene-smoking interaction are associated with susceptibility to tuberculosis

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