Adipocyte-derived ferroptotic signaling mitigates obesity

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成果类型：

期刊论文

作者：

Wang, Xue;Wu, Qian;Zhong, Meijuan;Chen, Ying;Wang, Yudi;...

通讯作者：

Wang, FD;Min, JX

作者机构：

[Wang, Junxia; Yu, Yingying; Wang, Xinhui; Wang, Tianyi; Wang, Yudi; Wang, Xue; Zhao, Wenxi; Min, JX; Ge, Chaodong] Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med, Hangzhou 310058, Peoples R China.

[Xie, Enjun; Wang, Xinhui; Wang, Fudi; Wang, Yudi; Zhao, Wenxi; Yang, Sisi; Shi, Wanting] Zhejiang Univ, Affiliated Hosp 2, State Key Lab Expt Hematol, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China.

[Wang, Fudi; Wang, Tianyi; Li, Xin; Wang, Yudi; Wang, Xue; Zhao, Wenxi; Zhong, Meijuan] Univ South China, Affiliated Hosp 1, Basic Med Sci, Hengyang Med Sch,Sch Pharmacol,Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Wang, Fudi; Li, Xin; Wang, Xue; Ge, Chaodong] Xinxiang Med Univ, Sch Publ Hlth, Sch Basic Med Sci, Xinxiang 453003, Peoples R China.

[Yu, Yingying; Wu, Qian] Zhejiang Univ, Affiliated Hosp 4, Int Inst Med, Sch Med, Yiwu, Zhejiang, Peoples R China.

通讯机构：

[Wang, FD ; Min, JX ] Z

Zhejiang Univ, Affiliated Hosp 2, State Key Lab Expt Hematol, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med, Hangzhou 310058, Peoples R China.

Univ South China, Affiliated Hosp 1, Basic Med Sci, Hengyang Med Sch,Sch Pharmacol,Sch Publ Hlth, Hengyang 421001, Peoples R China.

Xinxiang Med Univ, Sch Publ Hlth, Sch Basic Med Sci, Xinxiang 453003, Peoples R China.

语种：

英文

关键词：

5,15-DiHETE;5,15-dihydroxyeicosatetraenoic acid;ACSL4;HIF1α;acyl-coenzyme A synthetase long-chain family member 4;adipose tissue;ferritin;ferrology;ferroptosis;ferroptotic signaling;hypoxia-inducible factor-1α;iron metabolism;obesity

期刊：

Cell Metabolism

ISSN：

1550-4131

年：

2025

卷：

期：

页码：

673-691.e7

DOI：

10.1016/j.cmet.2024.11.010

基金类别：

China Postdoctoral Science Foundation National Natural Science Foundation of China#&#&#31930057#&#&#82030003#&#&#32300988#&#&#32330047#&#&#32171166#&#&#82471593 Postdoctoral Research Foundation of China#&#&#2022M712733

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Ferroptosis is characterized as an iron-dependent and lipophilic form of cell death. However, it remains unclear what role ferroptosis has in adipose tissue function and activity. Here, we find a lower ferroptotic signature in the adipose tissue of individuals and mice with obesity. We further find that activation of ferroptotic signaling by a non-lethal dose of ferroptosis agonists significantly reduces lipid accumulation in primary adipocytes and high-fat diet (HFD)-fed mice. Notably, adipocyte-specific overexpression of acyl-coenzyme A synth...

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Adipocyte-derived ferroptotic signaling mitigates obesity

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