Tumor necrosis factor-α-inducing protein of Helicobacter pylori promotes epithelial-mesenchymal transition and cancer stem-like cells properties via activation of Wnt/β-catenin signaling pathway in gastric cancer cells

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成果类型：

期刊论文

作者：

Guo, Kaiyun;Duan, Jie;Lu, Jingwen;Xiao, Lingqiao;Han, Liang;...

通讯作者：

Yan Zhang

作者机构：

[Duan, Jie; Han, Liang; Xiao, Lingqiao; Zeng, Shasha; Li, Wenjing; Huang, Lijun; Zhang, Yan; Lu, Jingwen; Guo, Kaiyun] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Duan, Jie; Han, Liang; Xiao, Lingqiao; Zeng, Shasha; Li, Wenjing; Huang, Lijun; Zhang, Yan; Lu, Jingwen; Guo, Kaiyun] Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Duan, Jie; Han, Liang; Xiao, Lingqiao; Zeng, Shasha; Li, Wenjing; Huang, Lijun; Zhang, Yan; Lu, Jingwen; Guo, Kaiyun] Univ South China, Hunan Prov Innovat Training Base Postgrad, Hengyang 421001, Hunan, Peoples R China.

[Duan, Jie; Han, Liang; Xiao, Lingqiao; Zeng, Shasha; Li, Wenjing; Huang, Lijun; Zhang, Yan; Lu, Jingwen; Guo, Kaiyun] Nanyue Biopharmaceut Co Ltd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xin] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yan Zhang] I

Institute of Pathogenic Biology, Hengyang Medical College, University of South China

Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control

Hunan Province Innovative Training Base for Postgraduates, University of South China and Nanyue Biopharmaceutical Co. Ltd. , Hengyang 421001, Hunan, China

语种：

英文

关键词：

Helicobacter pylori;Tipα;gastric cancer stem cells;EMT;Wnt/β-catenin pathway

期刊：

Pathogens and Disease

ISSN：

2049-632X

年：

2022

卷：

期：

DOI：

10.1093/femspd/ftac025

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province [grant number 2021JJ30605], the Grant For Key Projects of Hunan Provincial Education Department [grant number 19A423], Construct Program of the ‘Double First-Class discipline’ of University of South China [grant number 2020SYL] and the Undergraduates Innovation Experimental Program of Hunan Province [grant number S202110555322].

机构署名：

本校为第一机构

院系归属：

医学院

护理学院

摘要：

Tumor necrosis factor-α-inducing protein (Tipα) is a newly identified toxin that promotes the inflammation and carcinogenesis caused by Helicobacter pylori. However, its mechanism of pathogenesis is still unclear. To investigate the carcinogenic mechanisms of Tipα, SGC7901 cells and SGC7901-derived cancer stem-like cells (CSCs) were stimulated by recombinant Tipα with or without Wnt/β-catenin signaling inhibitor XAV939. qRT-PCR and Western blotting were employed to detect expression of epithelial-mesenchymal transition (EMT), CSCs markers ...

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Tumor necrosis factor-α-inducing protein of Helicobacter pylori promotes epithelial-mesenchymal transition and cancer stem-like cells properties via activation of Wnt/β-catenin signaling pathway in gastric cancer cells

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