期刊论文

Zhang, Yan

英文

Biochemical and Biophysical Research Communications

0006-291X

2017

484

2

311-317

10.1016/j.bbrc.2017.01.110

This work was supported by the Construct Program of the Key Discipline in Hunan Province (No. 2011-75), Hunan Provincial Key Laboratory for Special Pathogen Prevention and Control Foundation (Grant No. 2014-5), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (No. 2015-351), and the Research Project of Hunan Provincial Education Department (No. 16K078).

本校为第一且通讯机构

Tumor necrosis factor (TNF)-alpha-inducing protein (Tip alpha) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H.pylori). Although it has been proved that Tipa is a strong inducer of epithelialmesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric cancer. In this study, we showed that Tipa significantly down-regulated the...