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TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway

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成果类型:
期刊论文
作者:
Chen, Guodong;Tang, Na;Wang, Chao;Xiao, Linqiao;Yu, Minjun;...
通讯作者:
Zhang, Yan
作者机构:
[Han, Liang; Wang, Chao; Chen, Guodong; Tang, Na; Zhao, Lanhua; Cai, Hengling; Xie, Chengyuan; Yu, Minjun; Zhang, Yan; Xiao, Linqiao] Univ South China, Coll Med, Inst Pathogen Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zhang, Yan] U
Univ South China, Coll Med, Inst Pathogen Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Helicobacter pylori;TNF-alpha inducing protein (Tip alpha);IL-6/STAT3 pathway;Gastric cancer;Epithelial-mesenchymal transition (EMT)
期刊:
Biochemical and Biophysical Research Communications
ISSN:
0006-291X
年:
2017
卷:
484
期:
2
页码:
311-317
基金类别:
This work was supported by the Construct Program of the Key Discipline in Hunan Province (No. 2011-75), Hunan Provincial Key Laboratory for Special Pathogen Prevention and Control Foundation (Grant No. 2014-5), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (No. 2015-351), and the Research Project of Hunan Provincial Education Department (No. 16K078).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric cancer. In this study, we sho...

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