High glucose condition inhibits trophoblast proliferation, migration and invasion by downregulating placental growth factor expression

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成果类型：

期刊论文

作者：

Tao, Jun;Xia, Lin-Zhen;Chen, Jiao-Jiao;Zeng, Jun-Fa;Meng, Jun*;...

通讯作者：

Meng, Jun;Wu, ShiYuan;Wang, Zuo

作者机构：

[Zeng, Jun-Fa; Tao, Jun; Xia, Lin-Zhen; Chen, Jiao-Jiao; Wang, Zuo] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hunan Int Sci & Technol Cooperat Base Arterioscle, Inst Cardiovasc Dis,Hengyang Med Coll, Hengyang, Peoples R China.

[Meng, Jun] Univ South China, Funct Dept, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Wu, ShiYuan] YueYang Maternal Child Med Hlth Hosp, Hunan Prov Innovat Training Base Med Postgrad, Yueyang 416000, Hunan, Peoples R China.

[Wang, Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Heng Yang Med Sch, Hengyang City 421001, Peoples R China.

通讯机构：

[Meng, Jun; Wang, Zuo] U

[Wu, ShiYuan] Y

Univ South China, Funct Dept, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

YueYang Maternal Child Med Hlth Hosp, Hunan Prov Innovat Training Base Med Postgrad, Yueyang 416000, Hunan, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Heng Yang Med Sch, Hengyang City 421001, Peoples R China.

语种：

英文

关键词：

glucose;messenger RNA;placental growth factor;Article;cell invasion;cell migration;cell proliferation;cell viability;controlled study;down regulation;fluorescence microscopy;human;human cell;immunofluorescence;preeclampsia;pregnancy diabetes mellitus;protein analysis;protein expression;protein function;real time polymerase chain reaction;trophoblast;Western blotting

期刊：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

ISSN：

1341-8076

年：

2020

卷：

期：

页码：

1690-1701

DOI：

10.1111/jog.14341

基金类别：

This study was supported by the Natural Science Foundation of China (No. 81970389).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aim: This study aimed to investigate the effect of high glucose (HG) level on the proliferation, migration and invasion of trophoblasts and determine the role of placental growth factor (PLGF) in the process. Methods: HTR8-S/Vneo was treated with different concentrations of d-glucose (0, 10, 15, 20, 25 and 30 μM) at different times (0, 6, 12 and 24 h). qRT-PCR and Western blot analyses were used to measure PLGF expression. The protein level of PLGF was measured by immunofluorescence. Cell proliferation was assessed with CCK-8 analysis. Wound h...

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High glucose condition inhibits trophoblast proliferation, migration and invasion by downregulating placental growth factor expression

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