期刊论文

中文

吉林大学学报(医学版)

1671-587X

2022

48

3

668-675

10.13481/j.1671-587X.20220315

湖南省教育厅科研项目（19C1618）； 湖南省卫健委科研项目（20200881）；

本校为第一机构

目的:观察重楼皂苷Ⅶ (PP Ⅶ)对重症急性胰腺炎(SAP)大鼠急性肺损伤的保护作用,并探讨其可能作用机制。方法:将75只大鼠随机分成假手术组、模型组、地塞米松组(阳性对照,给予2 mg·kg~(-1)地塞米松)、低剂量PP Ⅶ组(给予50 mg·kg~(-1)PP Ⅶ)和高剂量PP Ⅶ组(给予150 mg·kg~(-1)PP Ⅶ),每组15只。除假手术组外,其他各组大鼠采用逆行胆胰管注射5% 牛磺胆酸钠溶液法建立SAP大鼠模型,术后立即给予相应药物处理。检测各组大鼠动脉血氧合指数(OI)和肺组织湿/干质量(W/D)比值,ELISA法检测各组大鼠血清脂肪酶和淀粉酶水平及支气管肺泡灌洗液(BALF)中白细胞介素1β (IL-1β)、白细胞介素6 (IL-6)和肿瘤...

Objective:To observe the protective effect of polyphyllinⅦ(PPⅦ)on acute lung injury of the rats with severe acute pancreatitis(SAP),and to explore its possible mechanism.Methods:Seventy-five rats were randomly divided into sham operation group,model group,dexamethasone group(positive control,given 2 mg·kg-1 dexamethasone),low dose of PPⅦgroup(given 50 mg·kg-1 PPⅦ),and high dose of PPⅦgroup(given 150 mg·kg-1 PPⅦ),and there were 15 rats in each group.Except sham operation group,the SAP rat models were established by retrograde biliopancr...