期刊论文

中文

吉林大学学报(医学版)

1671-587X

2015

41

2

235-239

10.13481/j.1671-587x.20150206

国家自然科学基金资助课题（81202830）； 湖南省科技厅自然科学基金资助课题（11JJ2046）；

本校为第一机构

目的:观察气体信号分子硫化氢(H_2S)对糖尿病(DM)大鼠心肌纤维化和膜型基质金属蛋白酶1(MT1-MMP)和基质金属蛋白酶组织抑制因子2(TIMP-2)蛋白表达的影响,探讨其在心肌纤维化发生发展中的作用和相关机制。 方法:52只SD大鼠随机分为对照组(Control组)、糖尿病模型组(DM组)、硫化氢干预糖尿病组(DM+H_2S组)和硫化氢干预正常组(H_2S组),每组13只。以链脲佐菌素(STZ)腹腔注射建立DM大鼠模型,模型构建成功后对照组(n=12)和DM组(n=9)大鼠每天腹腔注射生理盐水;DM+H_2S组(n=9)和H_2S组(n=10)大鼠每天腹腔注射100 μmol·kg~(-1)硫氢化钠溶液,8周后处死大鼠取左心室心肌组织,VG染色观察大鼠心肌组织形态学...

Objective: To explore the effects of hydrogen sulfide (H2S) on the myocardial fibrosis and the expressions of membrane-type 1 matrixmetallo - proteinase (MT1-MMP) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the myocardium tissue of the rats with diabetes mellitus (DM), and to clarify the effect of H2S on the development of the myocardial fibrosis and its mechanism. Methods: 52 rats were randomly divided into control group, DM group, DM+H2S group and H2S group (re=13). The rat models were induced by intraperitoneal injection of strep...