The emerging roles of PD-L1 subcellular localization in tumor immune evasion

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成果类型：

期刊论文

作者：

Liu, Dandan;Wen, Chengcai;Chen, Lu;Ye, Mao;Liu, Hong;...

通讯作者：

Liang, Long;Liu, J;Chang, S;Zhang, J

作者机构：

[Sun, Xing; Liu, Jing; Liu, J; Liang, Long; Liu, Dandan; Wen, Chengcai] Cent South Univ, Sch Life Sci, Mol Biol Res Ctr, Hunan Prov Key Lab Basic & Appl Hematol,Ctr Med Ge, Changsha 410011, Hunan, Peoples R China.

[Chang, S; Chang, Shi; Chen, Lu] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha 410008, Hunan, Peoples R China.

[Ye, Mao] Hunan Univ, Coll Chem & Chem Engn, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Liu, Hong] Cent South Univ, Xiangya Clin Res Ctr Canc Immunotherapy, Hunan Key Lab Skin Canc & Psoriasis, Dept Dermatol,Hunan Engn Res Ctr Skin Hlth & Dis,X, Changsha 410008, Hunan, Peoples R China.

[Zhang, Ji; Zhang, J] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Clin Lab, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Liang, L; Chang, S ; Liu, J ] C

[Zhang, J ] U

Cent South Univ, Sch Life Sci, Mol Biol Res Ctr, Hunan Prov Key Lab Basic & Appl Hematol,Ctr Med Ge, Changsha 410011, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha 410008, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Clin Lab, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

Biomarker;Exosomes;Nuclear transportation;PD-L1;Post-translational modifications

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2024

卷：

220

页码：

115984

DOI：

10.1016/j.bcp.2023.115984

基金类别：

This work was supported by the grants from National Key Research and Development Program of China (2019YFE0120800 and 2019YFA0111600); National Natural Science Foundation of China (92253201, 81920108004, 81770107, 82203880 and 82370149); Fellowship of the China Postdoctoral Science Foundation (2022M720174 and 2023T160740); Natural Science Foundation of Hebei Province (F2021203102); Key Program of National Natural Science Foundation of China (U22A20329); Natural Science Foundation of China for CRediT authorship contribution statement Dandan Liu: Writing – original draft, Conceptualization. Chengcai Wen: Writing – original draft, Conceptualization. Lu Chen: Methodology. Mao Ye: Writing – review & editing. Hong Liu: Writing – review & editing, Supervision. Xing Sun: Writing – review & editing, Supervision, acquisition. Long Liang: Writing – review & editing, Supervision. Ji Zhang: Writing – review & editing, Supervision, acquisition. Shi Chang: Writing – review & editing. Jing Liu: Writing – review & editing,

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Targeting immune checkpoint PD-1 or its ligand PD-L1 blockade has achieved a great therapeutic effect in a variety of cancer types. However, the overall response rate and duration are still limited for intrinsic and acquired resistance. There is an urgent need to understand the underlying mechanism. Studies showed that PD-L1 regulation is related to the response to PD-1 monoclonal antibodies (PD-1 mAB). Interestingly, emerging studies found that the different distribution of PD-L1 has distinct functions in tumor through the specific signaling pathways. Thus, controlling the distribution of PD-...

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The emerging roles of PD-L1 subcellular localization in tumor immune evasion

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