Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells

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期刊论文

作者：

Saito, Suguru*;Okuno, Alato;Peng, Zhenzi;Cao, Duo-Yao;Tsuji, Noriko M.

通讯作者：

Saito, Suguru;Tsuji, NM;Saito, S

作者机构：

[Okuno, Alato; Tsuji, NM; Saito, Suguru; Tsuji, Noriko M.; Saito, S] Natl Inst Adv Ind Sci & Technol, Dept Life Technol & Sci, Div Cellular & Mol Engn, Tsukuba, Ibaraki, Japan.

[Saito, S; Saito, Suguru] Jichi Med Univ, Fac Med, Dept Infect & Immun, Div Virol, Shimotsuke, Tochigi, Japan.

[Cao, Duo-Yao; Saito, S; Saito, Suguru] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA.

[Okuno, Alato] Shibata Gakuen Univ, Fac Human Design, Dept Hlth & Nutr, Hirosaki, Aomori, Japan.

[Peng, Zhenzi] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Cell Biol & Genet, Hengyang, Hunan, Peoples R China.

通讯机构：

[Saito, S ] J

[Tsuji, NM ; Saito, S] N

Natl Inst Adv Ind Sci & Technol, Dept Life Technol & Sci, Div Cellular & Mol Engn, Tsukuba, Ibaraki, Japan.

Jichi Med Univ, Fac Med, Dept Infect & Immun, Div Virol, Shimotsuke, Tochigi, Japan.

Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA.

语种：

英文

关键词：

probiotics;lactic acid bacteria;dendritic cells;CD8+T cells;anti-tumor immunity;MHC class I;Immunoproteasome

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2024

卷：

DOI：

10.3389/fimmu.2024.1335975

基金类别：

Japan Society for the Promotion of Science [16H06814, 21K15958, 21K20573, 22K05543, 19H04042]; Mishima-Kaiun Memorial Fund; American Heart Association [23CDA1052548]; National Science Foundation of Hunan Province [2022JJ40382]; IMSUT Domestic Joint Research Project (NMT); AIST-Shizuoka Industrial innovation for the next generation (NMT)

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摘要：

Lactic acid bacteria (LAB) possess the ability to argument T cell activity through functional modification of antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages. Nevertheless, the precise mechanism underlying LAB-induced enhancement of antigen presentation in APCs remains incompletely understood. To address this question, we investigated the detailed mechanism underlying the enhancement of major histocompatibility complex (MHC) class I-restricted antigen presentation in DCs using a probiotic strain known as Lactococcus lactis subsp. Cremoris C60. We found that Heat-...

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Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells

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