Objective. To evaluate the therapeutic effect of Shengjing capsules on nonobstructive azoospermia (NOA) in the rat model.Methods. Twenty-five male Sprague–Dawley rats were randomly divided into five groups as follows (n=5per group): normal group, NOA group, and three Shengjing capsule treatment groups (low-dose, medium-dose, and high-dose groups, respectively). HE staining and semen smear were performed to assess sperm quality. The expression levels of PI3K/AKT and integrinα6/β1were measured by qRT-PCR and western blot analyses.Results. In t...