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Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin alpha6/beta1 in the NOA Rats.

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成果类型:
期刊论文
作者:
Wang, Jiamin;Zhao, Shankun;Luo, Lianmin;Liu, Yangzhou;Li, Ermao;...
通讯作者:
Zhao, Zhigang
作者机构:
[Wang, Jiamin; Liu, Yangzhou; Zhao, Shankun; Luo, Lianmin; Zhao, Zhigang; Zhu, Zhiguo] Guangzhou Med Univ, Affiliated Hosp 1, Guangdong Prov Key Lab Urol, Dept Urol & Androl,Minimally Invas Surg Ctr, Guangzhou, Guangdong, Peoples R China.
[Li, Ermao] Univ South China, Sch Med, Res Lab Clin & Translat Med, Hengyang 421001, Peoples R China.
通讯机构:
[Zhao, Zhigang] G
Guangzhou Med Univ, Affiliated Hosp 1, Guangdong Prov Key Lab Urol, Dept Urol & Androl,Minimally Invas Surg Ctr, Guangzhou, Guangdong, Peoples R China.
语种:
英文
期刊:
Evidence-Based Complementary and Alternative Medicine
ISSN:
1741-427X
年:
2019
卷:
2019
页码:
8494567
基金类别:
(is work was supported by the Science and Technology Planning Project of Guangdong Province (no. 2017B030314108).
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Objective. To evaluate the therapeutic effect of Shengjing capsules on nonobstructive azoospermia (NOA) in the rat model.Methods. Twenty-five male Sprague–Dawley rats were randomly divided into five groups as follows (n=5per group): normal group, NOA group, and three Shengjing capsule treatment groups (low-dose, medium-dose, and high-dose groups, respectively). HE staining and semen smear were performed to assess sperm quality. The expression levels of PI3K/AKT and integrinα6/β1were measured by qRT-PCR and western blot analyses.Results. In t...

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