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Echinacoside suppresses macrophage lipid accumulation and attenuates atherosclerosis via the MDM2/PPARγ/ABCA1 signaling axis

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成果类型:
期刊论文
作者:
Zhou, Qin-Yi;Zhou, Jing;Li, Zhao-Bing;Wang, Qun;Gong, Duo;...
通讯作者:
Duo Gong
作者机构:
[Zhou, Jing; Zhou, Qin-Yi; Li, Zhao-Bing] Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, The Affiliated Nanhua Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China
[Zhou, Jing] Chongqing Creation Vocational College, Yongchuan 402160, Chongqing, China
[Wang, Qun] Department of Cardiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
[Gong, Duo] Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, The Affiliated Nanhua Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. Electronic address: gong-duo@usc.edu.cn
[Liu, Wang] Department of Gastrointestinal Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. Electronic address: 1377621039@qq.com
通讯机构:
[Duo Gong] I
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, The Affiliated Nanhua Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China
语种:
英文
关键词:
ATP-binding cassette transporter A1;Atherosclerosis;Cholesterol efflux;Echinacoside;Murine double minute 2;Peroxisome proliferator-activated receptor-gamma
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
ISSN:
1388-1981
年:
2025
卷:
1870
期:
7
页码:
159681
基金类别:
CRediT authorship contribution statement Qin-Yi Zhou: Writing – review & editing, Writing – original draft, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Jing Zhou: Writing – review & editing, Writing – original draft, Methodology, Formal analysis, Conceptualization. Zhao-Bing Li: Writing – review & editing, acquisition. Qun Wang: Writing – review & editing, Methodology. Duo Gong: Writing – review & editing, Conceptualization. Wang Liu: Writing – review & editing, Writing – original draft,
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Macrophage cholesterol efflux, a critical step in reverse cholesterol transport, plays a pivotal role in the attenuation of atherosclerosis. Echinacoside, a natural compound with anti-inflammatory, antioxidant, and antitumor properties, has emerged as a potential therapeutic agent for atherosclerosis. However, the mechanisms underlying its anti-atherosclerotic effects remain unclear. In this study, we aimed to investigate the effects of echinacoside on lipid accumulation in macrophage-derived foam cells and on atherosclerotic progression in apo...

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