BACKGROUND: Sentinel lymph node (SLN) biopsy (SLNB) is considered the gold standard for detecting SLN metastases in patients with invasive ductal breast cancer (IDC). However, SLNB is invasive and associated with several complications. Thus, this study aimed to evaluate the diagnostic performance of a non-invasive radiomics analysis utilizing 2-deoxy-2-[(18)F]fluoro-d-glucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for assessing SLN metastasis in IDC patients. METHODS: This retrospective study included 132 patients with biopsy-confirmed IDC, who underwent (18)F-FDG ...