Purpose: To study the effect of curcumin on proliferation and invasion of the human retinoblastoma cells and its potential mechanism. Methods: A cell line of retinoblastoma (WERI-Rb-1) was treated with various concentrations of curcumin (0–40µM). Cell number was counted with CCK8 kit, and cell migration was assessed using the Transwell assay. Immunoblotting was performed to detect the proteins of metalloproteinase-2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF) as well as nuclear translocation of nuclear factor-κB (NF-κB, p65...