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Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-κB pathway

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成果类型:
期刊论文
作者:
Mu, Ying-Tao;Feng, Huan-Huan;Yu, Jin-Qiang;Liu, Zhen-Kai;Wang, Yan;...
通讯作者:
Li, De-Kun
作者机构:
[Li, De-Kun; Shao, Jie; Mu, Ying-Tao; Yu, Jin-Qiang; Liu, Zhen-Kai; Wang, Yan] Hubei Univ Med, Shiyan Renmin Hosp, Dept Ophthalmol, 39 Middle Chaoyang Rd, Shiyan 442000, Hubei, Peoples R China.
[Feng, Huan-Huan] Hubei Univ Med, Xiangyang 1 Peoples Hosp, Xiangyang, Hubei, Peoples R China.
[Li, Ran-Hui] Univ South China, Inst Pathogen Biol, Heyang, Hunan, Peoples R China.
通讯机构:
[Li, De-Kun] H
Hubei Univ Med, Shiyan Renmin Hosp, Dept Ophthalmol, 39 Middle Chaoyang Rd, Shiyan 442000, Hubei, Peoples R China.
语种:
英文
关键词:
curcumin;gelatinase A;gelatinase B;immunoglobulin enhancer binding protein;transcription factor RelA;vasculotropin;curcumin;gelatinase A;immunoglobulin enhancer binding protein;vasculotropin A;antineoplastic activity;Article;cell count;cell migration;cell proliferation;concentration response;controlled study;human;human cell;immunoblotting;NF kB signaling;polyacrylamide gel electrophoresis;protein analysis;protein expression;protein function;retinoblastoma;signal transduction;WERI-Rb-1 cell line;cell proliferation;retina tumor;retinoblastoma;tumor cell line;Cell Line, Tumor;Cell Proliferation;Curcumin;Humans;Matrix Metalloproteinase 2;NF-kappa B;Retinal Neoplasms;Retinoblastoma;Vascular Endothelial Growth Factor A
期刊:
INTERNATIONAL OPHTHALMOLOGY
ISSN:
0165-5701
年:
2020
卷:
40
期:
10
页码:
2435-2440
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Purpose: To study the effect of curcumin on proliferation and invasion of the human retinoblastoma cells and its potential mechanism. Methods: A cell line of retinoblastoma (WERI-Rb-1) was treated with various concentrations of curcumin (0–40µM). Cell number was counted with CCK8 kit, and cell migration was assessed using the Transwell assay. Immunoblotting was performed to detect the proteins of metalloproteinase-2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF) as well as nuclear translocation of nuclear factor-κB (NF-κB, p65...

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