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Identification and validation of potential long non-coding RNA biomarkers in predicting survival of patients with head and neck squamous cell carcinoma.

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成果类型:
期刊论文
作者:
Li, Junyu;Li, Yuehua;Wu, Xiaoping;Li, Ying*
通讯作者:
Li, Ying
作者机构:
[Li, Junyu] Canc Hosp Jiangxi Prov, Dept Radiotherapy, Nanchang 330029, Jiangxi, Peoples R China.
[Li, Yuehua; Wu, Xiaoping] Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.
[Li, Ying] Hubei Canc Hosp, Dept Radiat Oncol, 116 Zhuodaoquan South Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Li, Ying] H
Hubei Canc Hosp, Dept Radiat Oncol, 116 Zhuodaoquan South Rd, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
biomarker;head and neck squamous cell carcinoma;long non-coding RNA;signature;survival
期刊:
ONCOLOGY LETTERS
ISSN:
1792-1074
年:
2019
卷:
17
期:
6
页码:
5642-5652
基金类别:
Hubei Province Health and Family Planning Scientific Research Project [WJ2017M145]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer and their aberrant expression has been associated with cancer diagnosis and prognosis, which suggests that they may be promising molecular biomarkers. However, understanding of the expression pattern of lncRNAs and their prognostic roles in head and neck squamous cell carcinoma (HNSCC) is relatively limited. In the current study, the prognostic value of lncRNA expression profiles in predicting the OS of patients with HNSCC was investigated by integrating clinical and profiling data from The Cancer Genome Atlas. A total of ten...

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