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Trifolirhizin inhibits proliferation, migration and invasion in nasopharyngeal carcinoma cells via PI3K/Akt signaling pathway suppression

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成果类型:
期刊论文
作者:
Jiang, Xing;Yin, Haihui;Su, Wenqing;Quan, Haiyan;Yuan, Xinye;...
通讯作者:
Xiao, Junhui;Li, R
作者机构:
[Li, Pei; Li, Rong; He, Yan; Li, R; Yuan, Xinye; Feng, Xu; Jiang, Xing; Xiao, Junhui; Xiao, JH] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.
[Yin, Haihui] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Med Ultrasound, Hengyang 421001, Hunan, Peoples R China.
[Su, Wenqing] Youjiang Med Univ Nationalities, Baise 533000, Guangxi, Peoples R China.
[Quan, Haiyan] Hunan Polytech Environm & Biol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Li, R ; Xiao, JH] U
Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Invasion;Migration;Nasopharyngeal carcinoma;Proliferation;Signaling pathway
期刊:
Biochemical and Biophysical Research Communications
ISSN:
0006-291X
年:
2023
卷:
667
页码:
111-119
基金类别:
Author contributions Rong Li and Junhui Xiao provided project management and secured funding. Xing Jiang and Haihui Yin were responsible for conceptualizing the experiment, conducting the cell experiments, and writing the manuscript. Wenqing Su conducted the animal experiments, Haiyan Quan was responsible for HE staining, Xinye Yuan and Xu Feng performed cell sequencing and result analysis, Pei Li and Yan He completed the Data Curation and Analysis. All authors have confirmed and agreed upon these author Declaration of competing interest The authors declare that there are no potential conflicts of interest with regards to any funding or sponsorship acquired for my research.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Nasopharyngeal carcinoma (NPC) is a highly recurrent and metastatic malignant tumor affecting a large number of individuals in southern China. Traditional Chinese herbal medicine has been found to be a rich source of natural compounds with mild therapeutic effects and minimal side effects, making them increasingly popular for treating various diseases. Trifolirhizin, a natural flavonoid derived from legu-minous plants, has gained significant attention for its therapeutic potential. In this study, we confirmed that trifolirhizin could effectively inhibit the proliferation, migration and invasio...

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