miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w

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成果类型：

期刊论文

作者：

Yang, Xiaoyan;Yin, Jie;Yu, Jia;Xiang, Qiong;Liu, Yunmei;...

通讯作者：

Lei, Xiaoyong

作者机构：

[Yang, Xiaoyan; Liu, Yunmei; Yin, Jie; Tang, Shensong; Xiang, Qiong; Liao, Duanfang; Yu, Jia; Zhu, Bingyang] Univ S China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ S China, Coll Pharm & Life Sci, Hengyang 421001, Hunan, Peoples R China.

[Tang, Huifang; Zu, Xuyu] Univ S China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ S China, Coll Pharm & Life Sci, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lei, Xiaoyong] U

Univ S China, Coll Pharm & Life Sci, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

miR-195;Bcl-w;5-Fluorouracil;hepatocellular carcinoma

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2012

卷：

期：

页码：

250-257

DOI：

10.3892/or.2011.1472

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30900625]; Youth Foundation of Education Department of Hunan Province, China [08A059]; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The role of microRNA-195 in developing acquired drug resistance in hepatocellular carcinoma cells was investigated. Expression pro fi ling of miRNAs revealed a limited set of miRNAs with altered expression in drug resistant hepatocellular carcinoma cell line BEL-7402/5-FU compared to its parental BEL-7402 cell line. Real-time PCR confirmed down-regulation of miRNA-195 in BEL-7402/5-FU cells. Overexpression of miRNA-195 sensitized BEL-7402/5-FU cells to anticancer drugs. Consistent with these findings, miR-195 antisense oligonucleotide induced drug resistance in BEL-7402/5-FU cells. Also, the b...

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miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w

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