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Acetyl-CoA carboxylase-α as a novel target for cancer therapy

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成果类型:
期刊论文
作者:
Wang, Chun;Rajput, Sandeep;Watabe, Kounosuke;Liao, Duan-Fang;Cao, Deliang
通讯作者:
Cao, D.
作者机构:
School of Pharmaceutical Sciences, Central South University, Changsha, 410083, China
Institute of Pharmacy and Pharmacology, College of Science and Technology, University of South China, Hengyang, 421001, China
[Cao, Deliang; Rajput, Sandeep; Watabe, Kounosuke] Department of Medical Microbiology, Immunology, and Cell Biology, Simmons Cooper Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, United States
[Wang, Chun] School of Pharmaceutical Sciences, Central South University, Changsha, 410083, China, Institute of Pharmacy and Pharmacology, College of Science and Technology, University of South China, Hengyang, 421001, China, Department of Medical Microbiology, Immunology, and Cell Biology, Simmons Cooper Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, United States
[Liao, Duan-Fang] School of Pharmaceutical Sciences, Central South University, Changsha, 410083, China, Institute of Pharmacy and Pharmacology, College of Science and Technology, University of South China, Hengyang, 421001, China
通讯机构:
[Cao, D.] D
Department of Medical Microbiology, Immunology, and Cell Biology, Simmons Cooper Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, United States
语种:
英文
关键词:
Acetyl-CoA;Alpha;Carboxylase;Review;Target cancer;Therapy
期刊:
Frontiers in Bioscience - Scholar
ISSN:
1945-0516
年:
2010
卷:
2
期:
2
页码:
515-526
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Acetyl-CoA carboxylases (ACC) are rate-limiting enzymes in de novo fatty acid synthesis, catalyzing ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. Malonyl-CoA is a critical bi-functional molecule, i.e., a substrate of fatty acid synthase (FAS) for acyl chain elongation (fatty acid synthesis) and an inhibitor of carnitine palmitoyltransferase I (CPT-I) for fatty acid beta-oxidation. Two ACC isoforms have been identified in mammals, i.e. ACC-alpha (ACCA, also termed ACC1) and ACC-beta (ACCB, also designated ACC2). ACC has long been used as a target for the management of metabolic...

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