Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

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成果类型：

期刊论文

作者：

Wang, Chun;Xu, Canxin;Sun, Mingwei;Luo, Dixian;Liao, Duan-fang;...

通讯作者：

Cao, Deliang

作者机构：

[Sun, Mingwei; Wang, Chun; Luo, Dixian; Cao, Deliang] So Illinois Univ, Sch Med, SimmonsCooper Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62702 USA.

[Liao, Duan-fang; Wang, Chun] Cent S Univ, Sch Pharmaceut Sci, Changsha 410083, Peoples R China.

[Liao, Duan-fang; Wang, Chun; Xu, Canxin] Univ S China, Coll Sci & Technol, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Cao, Deliang] So Illinois Univ, Sch Med, SimmonsCooper Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N,Rutledge St, Springfield, IL 62702 USA.

通讯机构：

[Cao, Deliang] S

So Illinois Univ, Sch Med, SimmonsCooper Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N,Rutledge St, Springfield, IL 62702 USA.

语种：

英文

关键词：

Acetyl-CoA carboxylase-α;Apoptosis;Cancer;Fatty acid synthesis;TOFA

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2009

卷：

385

期：

页码：

302-306

DOI：

10.1016/j.bbrc.2009.05.045

基金类别：

NCI NIH HHS [R21 CA122327, R21 CA122622-01A2, CA122622, R21 CA122327-01A1, CA122327, R21 CA122622]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Acetyl-CoA carboxylase-α (ACCA) is a rate-limiting enzyme in long chain fatty acid synthesis, playing a critical role in cellular energy storage and lipid synthesis. ACCA is upregulated in multiple types of human cancers and small interfering RNA-mediated ACCA silencing in human breast and prostate cancer cells results in oxidative stress and apoptosis. This study reports for the first time that TOFA (5-tetradecyloxy-2-furoic acid), an allosteric inhibitor of ACCA, is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and ...

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Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

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