Objective To investigate the acute toxicity of scutellarin in mice and to evaluate its safety. Methods Sixty mature healthy mice were randomly divided into 6 groups. After scutcllarin was administered gastrically for 14 days, a series of indexes : symptom, sign, diet, and excrement of the mice were observed. All mice were put to death at the end of experiment and abnormalities were examined. Results Scutellarin with the largest dose ( 800 rag/kg) and below the dose had no obvious toxic response to the mouse. Conclusion Scutella...