期刊论文

中文

时珍国医国药

1008-0805

2007

18

2

292-294

10.3969/j.issn.1008-0805.2007.02.017

基金项目：湖南省衡阳市科委资助课题（No.2005ks01-43）.

本校为第一机构

目的 观察葛根素对糖尿病肾病内皮素表达的影响.方法 利用链脲佐菌素腹腔注射法诱导建立1型糖尿病大鼠模型,将实验用SD大鼠随机分正常对照组、糖尿病组、葛根素治疗组.治疗12周,观察治疗期间及治疗后大鼠的一般状况、血糖、尿素氮、血肌酐,内生肌酐清除率、24 h尿蛋白排泄率,免疫组织化学检测肾小球ET表达.结果 造模组大鼠均出现肾脏功能损害;葛根素能改善基本状况,降低糖尿病大鼠的尿素氮、血肌酐、24 h尿白蛋白排泄率,增加内生肌酐清除率,ET表达显著降低.结论 葛根素具有确切的肾脏保护作用.

Objective To observe the effect of puerarin on endothelin of streptozotocin - induced diabetic rats. Methods Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were divided into normal control group, model group, and Puerarin group for 12 weeks. During and after the treatment , the general state, blood glucose levels, blood urea nitrogen, serum creatinine, urinary albumin excretion rate of the 24 - hours, and clearance rate of creatinine, as well as endothelin were detected by immunohistochemical technology in diff...