Disruption of CLOCK-BMAL1 Transcriptional Activity Is Responsible for Aryl Hydrocarbon Receptor–Mediated Regulation of Period1 Gene

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Can-Xin;Krager, Stacey L.;Liao, Duan-Fang;Tischkau, Shelley A.*

通讯作者：

Tischkau, Shelley A.

作者机构：

[Tischkau, Shelley A.; Xu, Can-Xin] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62974 USA.

[Liao, Duan-Fang; Xu, Can-Xin] Univ S China, Inst Pharm & Pharmacol, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Krager, Stacey L.] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62974 USA.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

[Tischkau, Shelley A.] So Illinois Univ, Sch Med, Dept Pharmacol, 801 N Rutledge St, Springfield, IL 62974 USA.

通讯机构：

[Tischkau, Shelley A.] S

So Illinois Univ, Sch Med, Dept Pharmacol, 801 N Rutledge St, Springfield, IL 62974 USA.

语种：

英文

关键词：

Per1;"gene regulation";Ebox;" liver";"AhR activation";BMAL1;"circadian rhythm"

期刊：

Toxicological Sciences

ISSN：

1096-6080

年：

2010

卷：

115

期：

页码：

98-108

DOI：

10.1093/toxsci/kfq022

基金类别：

National Institute of Environmental Health SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [ES012948]; American Cancer SocietyAmerican Cancer Society; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES017774, R01ES017774, R21ES012948, R01ES017774, R21ES012948, R01ES017774, R01ES017774] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

国防科学技术学院

药学与生物科学学院

摘要：

The aryl hydrocarbon receptor (AhR) is a period-aryl hydrocarbon receptor nuclear transporter-simple minded domain transcription factor that shares structural similarity with circadian clock genes and readily interacts with components of the molecular clock. Activation of AhR by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters behavioral circadian rhythms and represses the Period1 (Per1) gene in murine hematopoietic stem and progenitor cells. Per1 expression is driven by circadian locomotor activity cycles kaput-brain muscle ARNT-like (CLOCK-B...

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Disruption of CLOCK-BMAL1 Transcriptional Activity Is Responsible for Aryl Hydrocarbon Receptor–Mediated Regulation of Period1 Gene

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