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A near-infrared BODIPY-based fluorescent probe for the detection of hydrogen sulfide in fetal bovine serum and living cells

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成果类型:
期刊论文
作者:
Zhang, Jian;Zhou, Junliang;Dong, Xiaochun;Zheng, Xing;Zhao, Weili
通讯作者:
Dong, Xiaochun(xcdong@fudan.edu.cn)
作者机构:
Fudan University
[Zhao, Weili; Zhang, Jian; Dong, Xiaochun] School of Pharmacy, Fudan University, Shanghai, 200120, China
[Zhou, Junliang; Zheng, Xing] Institute of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China
通讯机构:
[Dong, Xiaochun] Fudan Univ, Sch Pharm, Shanghai 200120, Peoples R China.
语种:
英文
关键词:
Detection limits - Detection of H - Fetal bovine serum - Fluorescent probes - Low toxicity - Michael addition reactions - Near infra red - Unsaturated double bonds
期刊:
RSC Advances
ISSN:
2046-2069
年:
2016
卷:
6
期:
56
页码:
51304-51309
基金类别:
NSFC [21372063]; Program for Changjiang Scholars and Innovative Research Team in University [PCS IRT1126]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
A near-infrared (NIR) "off-on" fluorescent probe BDP-680 was developed by taking advantage of the Michael addition reaction of unsaturated double bonds in conformationally restricted BODIPY to allow detection of H<inf>2</inf>S. The new probe possesses a highly selective and sensitive response to H<inf>2</inf>S. Such a NIR probe has been applied successfully to detect H<inf>2</inf>S in 10% deproteinized fetal bovine serum (FBS). The detection limit of the probe for NaSH in 10% deproteinized FBS sample was calculated to be about 1 &mu;M which is consistent with the value obtained from serum free solutions (0.5 &mu;M). The probe is of low toxicity and has been successfully used to detect H<inf>2</inf>S in living cells. &copy;2016 The Royal Society of Chemistry.

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