Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications

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成果类型：

期刊论文

作者：

Xu, Xiao Fan;Chen, Jie;Long, Lu hong;Zhang, Ao mei;Yang, Jing wen;...

通讯作者：

Xu, Yang;Cao, WY

作者机构：

[Yang, Jing wen; Xu, Yang; Zhang, Ao mei; Xu, Y; Xu, Xiao Fan; Cao, WY; Long, Lu hong; Cao, Wen Yu; Chen, Jie] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Xu, Xiao Fan] Liaocheng Peoples Hosp, Dept Neurosurg, Liaocheng 252000, Shandong, Peoples R China.

[Xu, Yang; Li, Yu jia] Univ South China, Inst Neurosci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Xiao Lin; Chen, Ling] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xu, Y; Cao, WY ] U

Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Depression;Hippocampus;Social isolation;Synaptic plasticity;m6A

期刊：

Journal of Affective Disorders

ISSN：

0165-0327

年：

2024

卷：

366

页码：

262-272

DOI：

10.1016/j.jad.2024.08.173

基金类别：

This research was funded by the National Natural Science Foundation of China (31701045 to Wenyu Cao) and the Hunan Provincial Natural Science Foundation of China (2022JJ30486 to Wenyu Cao) and (2022JJ30512 to Yang Xu). CRediT authorship contribution statement Xiao Fan Xu: Writing – original draft, Project administration, Methodology, Data curation. Jie Chen: Project administration, Methodology. Lu hong Long: Methodology. Ao mei Zhang: Methodology. Jing wen Yang: Methodology. Yu jia Li: Methodology. Ling Chen: Resources, Methodology. Xiao Lin Zhong: Resources, Methodology. Yang Xu: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Resources, Project administration, Methodology, Investigation, Funding

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Social isolation not only increases the risk of mortality in later life but also causes depressive symptoms, cognitive and physical disabilities. Although RNA m6A modifications are suggested to play key roles in brain development, neuronal signaling and neurological disorders, both the roles of m6A and the enzymes that regulate RNA m6A modification in social isolation induced abnormal behavior is unknown. The present study aims to explore the possible epitranscriptomic role of RNA m6A modifications and its enzymes in social isolation induced impaired behavior. METHODS: 3-4weeks mic...

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Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications

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