Estradiol-17beta inhibits homocysteine mediated damage by promoting H2 S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells.

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成果类型：

期刊论文

作者：

Zhang, Dandan;Hong, Xiuqin*;Wang, Jia;Jiang, Yu;Zhang, Ying;...

通讯作者：

Hong, Xiuqin

作者机构：

[Zhang, Dandan; Zhang, Ying; Wang, Jia; Chen, Jian; Hong, Xiuqin; Jiang, Yu; Niu, Xiaona] Hunan Normal Univ, Affiliated Hosp 1, Peoples Hosp Hunan Prov, Changsha 410000, Hunan, Peoples R China.

[Zhang, Dandan; Zhang, Ying; Chen, Jian; Jiang, Yu; Niu, Xiaona] Univ South China, Mawangdui Hosp, Hengyang, Peoples R China.

[Hong, Xiuqin; Jiang, Yu] Peoples Hosp Hunan Prov, Emergency Med Res Inst, Changsha, Hunan, Peoples R China.

通讯机构：

[Hong, Xiuqin] H

Hunan Normal Univ, Affiliated Hosp 1, Peoples Hosp Hunan Prov, Changsha 410000, Hunan, Peoples R China.

语种：

英文

关键词：

cystathine gamma-lyase;cystathionine beta-synthase;endogenous hydrogen sulfide;estrogen;homocysteine

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2021

卷：

122

期：

页码：

915-925

DOI：

10.1002/jcb.29527

基金类别：

Science and Technology Project of Changsha [kq1801097]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81202281, 81773530]

机构署名：

本校为其他机构

摘要：

Associated with reduced hydrogen sulfide (H2S) production in Hcy metabolic disorders, Plasma Hcy accumulation can bring about vascular dysfunction. Nevertheless, recently proposed therapies for vascular damage by estrogen could contribute to promoting endogenous hydrogen sulfide production. This study explores whether estrogen can come into play in protection in hyperhomocysteinemia and hypertensive patients at a population level, and then analyses the specific mechanism of estrogen protection in homocysteine (Hcy)-treated human umbilical vein endothelial cells (HUVECs) at the foundational lev...

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Estradiol-17beta inhibits homocysteine mediated damage by promoting H2 S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells.

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