Statin Treatment Improves Plasma Lipid Levels but not HDL Subclass Distribution in Patients Undergoing Percutaneous Coronary Intervention

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成果类型：

期刊论文

作者：

Tian, Li;Chen, Yucheng;Li, Chuanwei;Zeng, Zhi;Xu, Yanhua;...

通讯作者：

Fu, Mingde

作者机构：

[Tian, Li; Fu, Mingde] Sichuan Univ, W China Hosp, Lab Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China.

[Tian, Li; Fu, Mingde] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.

[Zeng, Zhi; Chen, Yucheng; Li, Chuanwei] Sichuan Univ, W China Hosp, Cardiovasc Dept, Chengdu 610041, Sichuan, Peoples R China.

[Xu, Yanhua] Chengdu Hoist Biotechnol Co Ltd, Chengdu, Sichuan, Peoples R China.

[Long, Shiyin] Univ S China, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Fu, Mingde] S

Sichuan Univ, State Key Lab Biotherapy, Room 902,New Bldg 6,16 Sect 3,People Rd S, Chengdu 610041, Peoples R China.

语种：

英文

关键词：

Coronary heart disease;High-density lipoprotein subclasses;Statins therapy;Quantitative coronary angiography;Two-dimensional gel electrophoresis-immunodetection

期刊：

Lipids

ISSN：

0024-4201

年：

2013

卷：

期：

页码：

127-137

DOI：

10.1007/s11745-012-3750-6

基金类别：

Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2010SCU11029]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [20110491719]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Despite the established efficacy of statin therapy, the risk of cardiovascular events remains high in many patients. We examined high-density lipoprotein (HDL) subclass distribution profiles among statin-treated coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI). Plasma HDL subclasses were measured in 85 patients with established CHD and quantified by two-dimensional gel electrophoresis and immunoblotting. In CHD patients with statin treatment, the mean value of total cholesterol (TC) reached the desirable...

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Statin Treatment Improves Plasma Lipid Levels but not HDL Subclass Distribution in Patients Undergoing Percutaneous Coronary Intervention

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