Mitophagy: A crucial modulator in the pathogenesis of chronic diseases

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成果类型：

期刊论文

作者：

Yang, Xiao;Pan, Weinan;Xu, Gaosheng*;Chen, Linxi*

通讯作者：

Xu, Gaosheng;Chen, Linxi

作者机构：

[Yang, Xiao; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Xu, Gaosheng] Yueyang Maternal & Child Hlth Care Hosp, Dept Breast Surg, Yueyang 414000, Hunan, Peoples R China.

[Pan, Weinan] Hunan Food & Drug Vocat Coll, 345 Bachelors Rd,Yue Lu Sci & Technol Ind Pk, Changsha, Hunan, Peoples R China.

[Xu, Gaosheng; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Xu, GS; Chen, LX] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Cancer;Diabetes;Mitophagy;PD;PINK1/Parkin

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2020

卷：

502

页码：

245-254

DOI：

10.1016/j.cca.2019.11.008

基金类别：

This work was supported by the grants from the ‘ National Natural Science Foundation of China ’ (grant numbers: 81470434 ).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Mitophagy is an autophagic process through which damaged or dysfunctional mitochondria are specifically degraded to maintain cellular homeostasis. It is highly regulated by various signaling pathways such as the PTEN-induced putative kinase 1 (PINK1)/Parkin and NIP3-like protein X (NIX)/BNIP3 pathways. Additionally, it plays a crucial role in inducing some pathological processes. Notably, some evidence suggesting the association of mitophagy with the occurrence of chronic diseases such as Parkinson's disease (PD), cancer, diabetes, atherosclero...

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Mitophagy: A crucial modulator in the pathogenesis of chronic diseases

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