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Downregulation of selenium-binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma

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成果类型:
期刊论文
作者:
Tan, Xing;Liao, Li;Wan, Yan-Ping;Li, Mei-Xiang;Chen, Si-Han;...
通讯作者:
Zeng, Gu-Qing
作者机构:
[Liao, Li; Wan, Yan-Ping; Mo, Wen-Juan; Tan, Xing; Zeng, Gu-Qing; Huang, Li-Fang; Zhao, Qiong-Lan] Univ South China, Sch Nursing, 28 Changsheng Rd West, Hengyang 421001, Hunan, Peoples R China.
[Li, Mei-Xiang; Chen, Si-Han] Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zeng, Gu-Qing] U
Univ South China, Sch Nursing, 28 Changsheng Rd West, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Selenium-binding protein 1;Lung squamous cell carcinoma;Prognosis
期刊:
World Journal of Surgical Oncology
ISSN:
1477-7819
年:
2016
卷:
14
期:
1
页码:
1-8
基金类别:
National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470130, 81272959]; Doctoral Scientific Research Foundation of University of South China [2013XQD33]; Educational Committee of Hunan Province [15A164]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
护理学院
摘要:
We found that selenium-binding protein 1 (SBP1) was progressively decreased in the human bronchial epithelial carcinogenic processes. Knockdown of SBP1 in immortalized human bronchial epithelial cell line 16HBE cells significantly increased the efficiency of B[a]P-induced cell transformation. However, the relationship between SBP1 expression and clinicopathological factors of patients has not been defined completely. The specific role of SBP1 in prognosis of lung squamous cell carcinoma (LSCC) is still unknown. Tissue samples from 82 patients t...

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