期刊论文

Yang, F

英文

TOXINS

2072-6651

2023

15

7

427-

10.3390/toxins15070427

Conceptualization, M.A.O.; Methodology, M.A.O.; Formal analysis, Y.Y.; Data curation, Y.Y. and L.C.; Writing—original draft, Y.L.; Writing—review and editing, C.Y., Y.L. and F.Y.; Supervision, I.Y.M.; Funding acquisition, C.Y., F.Y. All authors have read and agreed to the published version of the manuscript. This work was supported by the Hunan Province Excellent Youth Fund (2020JJ3053); the National Natural Science Foundation of China (81773393); the Key Research and Development Projects in Hunan Province (2019SK2041); the Natural Science Joint Fund of Hunan Province (2021JJ50096).

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Cyanobacterial blooms are considered a serious global environmental problem. Recent studies provided evidence for a positive association between exposure to microcystin-LR (MC-LR) and cardiotoxicity, posing a threat to human cardiovascular health. However, there are few studies on the cardiotoxic effects and mechanisms of long-term low-dose MC-LR exposure. Therefore, this study explored the long-term toxic effects and toxic mechanisms of MC-LR on the heart and provided evidence for the induction of cardiovascular disease by MC-LR. C57BL/6 mice were exposed to 0, 1, 30, 60, 90, and 120 & mu;g/L...