Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gong, Duo;Cheng, Hai-peng;Xie, Wei;Zhang, Min;Liu, Dan;...

通讯作者：

Tang, Chao-ke;Wang, Zong-bao

作者机构：

[Gong, Duo; Zhao, Zhen-wang; Lan, Gang; Xia, Xiao-dan; Zhang, Min; Liu, Dan; Tang, Chao-ke; Tan, Yu-lin; Cheng, Hai-peng; Li, Liang; Xie, Wei; Yao, Feng; Chen, Ling-yan; Huang, Chong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target NewDru, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zong-bao] Univ South China, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zong-bao] Univ South China, Life Sci Coll, Med Res Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-ke; Wang, Zong-bao] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target NewDru, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Life Sci Coll, Med Res Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;CSE;Cholesterol efflux;Endogenous H(2)S;PI3K/AKT pathway;miR-216a

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2016

卷：

470

期：

页码：

107-116

DOI：

10.1016/j.bbrc.2016.01.003

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81570408 , 81370377 , 81170278 and 81300224 ), the construct program of the key discipline in Hunan province, and Zheng Xiang Scholar Program of University of South China (2014-004).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

This study was designed to evaluate whether CSE/H2S system, which is regulated by miR-216a, regulated ABCA1-mediated cholesterol efflux and cholesterol contents in THP-1 macrophages-derived foam cells. Our qPCR and western blotting results showed that CSE/H2S significantly up-regulated the expression of ATP-binding cassette transporter A1 (ABCA1) mRNA and protein via PI3K/AKT pathway in foam cells derived from human THP-1 macrophages. The miR-216a directly targeted 3′ untranslated region of CSE. It significantly reduced CSE and ABCA1 expressio...

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Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway

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