The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids

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成果类型：

期刊论文

作者：

Liu, Xudong;Yang, Chao;Chen, P.;Zhang, Lei;Cao, Yi

通讯作者：

Lei Zhang<&wdkj&>Yi Cao

作者机构：

[Liu, Xudong] Moutai Inst, Dept Food Sci & Engn, Renhuai 564507, Peoples R China.

[Yang, Chao] Zhejiang Ocean Univ, Inst Innovat & Applicat, Natl Engn Res Ctr Marine Aquaculture, Zhoushan 316022, Zhejiang, Peoples R China.

[Chen, P.; Zhang, Lei] Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada.

[Chen, P.; Zhang, Lei] Univ Waterloo, Waterloo Inst Nanotechnol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada.

[Chen, P.] Qilu Univ Technol, Adv Mat Inst, Shandong Acad Sci, Jinan 250014, Peoples R China.

通讯机构：

[Lei Zhang] D

[Yi Cao] H

Department of Chemical Engineering and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China

语种：

英文

关键词：

3D brain organoids;Endoplasmic reticulum (ER) stress;Graphene oxide (GO);Lipidomics;Transcriptomics

期刊：

Science of The Total Environment

ISSN：

0048-9697

年：

2022

卷：

849

页码：

157815

DOI：

10.1016/j.scitotenv.2022.157815

基金类别：

The work was supported by Guizhou Provincial Science and Technology projects (Qiankehejichu-ZK[2022]yiban541) and Canada Mitacs Fellowship (Grant No. IT18262).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

The potential uses of graphene-based nanomaterials (NMs) in various fields lead to the concern about their neurotoxicity, considering that graphene-based NMs are capable to cross blood brain barrier (BBB) and enter central nervous system (CNS). Although previous studies reported the possibility of graphene-based NM exposure to alter lipid homeostasis in animals or cultured neurons, recent studies suggested the need to use 3D human brain organoids for mechanism-based toxicological studies as this model might better recapitulate the complex human...

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The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids

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