[Tian, Xiao-Ting; Ba, Hui-Xue; Cao, Yuan-Yuan; Li, Xiao-Hui] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410013, Peoples R China.

[Li, Ke] Hunan Acad Tradit Chinese Med, Changsha 410013, Hunan, Peoples R China.

[Li, Ying] Cent South Univ, Xiangya Hosp 3, Dept Hlth Management, Changsha, Peoples R China.

[Li, Xiao-Hui] Hunan Key Lab Bioanal Complex Matrix Samples, Changsha, Peoples R China.

[Wang, Aiping] Univ South China, Nanhua Affiliated Hosp, Inst Clin Res, Hengyang, Peoples R China.

[Ke Li] H

[Xiao-Hui Li] D

Hunan Academy of Traditional Chinese Medicine, Hunan, China<&wdkj&>Department of Pharmacology, Xiangya School of Pharmaceutical Science, Central South University, Changsha, China<&wdkj&>Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha, China

1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene;atrial natriuretic factor;brain natriuretic peptide;Dendrobium candidum aqueous extract;dye;eosin;hematoxylin;isoprenaline;Masson trichrome;messenger RNA;mitogen activated protein kinase;phalloidin;plant extract;unclassified drug;plant extract;animal cell;animal experiment;animal model;animal tissue;Article;cardiovascular parameters;cell stimulation;controlled study;Dendrobium;Dendrobium candidum;drug dose comparison;drug efficacy;drug mechanism;drug megadose;enzyme linked immunosorbent assay;female;gene expression;H9c2(2-1) cell line;heart left ventricle systolic pressure;heart left ventricle to tibia length;heart weight to body weight ratio;hypertrophy;immunoblotting;immunohistochemistry;in vitro study;in vivo study;isoproterenol-induced cardiac hypertrophy;low drug dose;male;MAPK signaling;nonhuman;protein blood level;protein expression;protein phosphorylation;rat;real time reverse transcription polymerase chain reaction;Sprague Dawley rat;treatment duration;animal;cardiac muscle;cardiac muscle cell;cardiomegaly;cell line;Dendrobium;drug effect;fibrosis;heart;MAPK signaling;metabolism;myoblast;pathology;signal transduction;Animals;Cardiomegaly;Cell Line;Dendrobium;Female;Fibrosis;Heart;Isoproterenol;Male;MAP Kinase Signaling System;Myoblasts;Myocardium;Myocytes, Cardiac;Plant Extracts;Rats;Rats, Sprague-Dawley;Signal Transduction

医学院