Dynamic Changes in Lysine Succinylation As Important Regulators of Erythropoiesis

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作者信息关键词期刊信息会议信息基础信息归属信息摘要

成果类型：

期刊论文、会议论文

作者：

Hu, Bin;Gong, Han;Yang, Chaoying;Nie, Ling;Zhang, Ji;...

作者机构：

[Liu, Jing; Hu, Bin; Gong, Han; Yang, Chaoying; Liang, Long] Cent South Univ, Mol Biol Res Ctr, Hunan Prov Key Lab Basic & Appl Hematol, Dept Hematol,Xiangya Hosp 2,Sch Life Sci, Changsha, Peoples R China.

[Nie, Ling] Cent South Univ, Xiangya Hosp, Dept Hematol, Changsha, Peoples R China.

[Zhang, Ji] Univ South China, Dept Clin Lab Med, Inst Microbiol & Infect Dis, Affiliated Hosp 1,Hengyang Med Sch, Hengyang, Peoples R China.

[Narla, Mohandas] New York Blood Ctr, Res Lab Red Cell Physiol, New York, NY USA.

[Sheng, Yue] Cent South Univ, Xiangya Hosp 2, Dept Hematol, Changsha, Peoples R China.

语种：

英文

期刊：

Blood

ISSN：

0006-4971

年：

2023

卷：

142

期：

SUPPL-1

页码：

2448

会议名称：

65th Annual Meeting of the American-Society-of-Hematology (ASH)

会议时间：

DEC 09-12, 2023

会议地点：

San Diego, CA

出版地：

2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA

出版者：

AMER SOC HEMATOLOGY

DOI：

10.1182/blood-2023-182646

机构署名：

本校为其他机构

摘要：

Lysine succinylation has emerged as a recently discovered protein modification that significantly impacts the chemical environment and exhibits diverse functions in various biological processes. However, the specific role of lysine succinylation in erythropoiesis has not been fully elucidated. In this study, we investigated the levels of six common acylations (acetylation, crotonylation, succinylation, propionylation, butyrylation, and malonylation) in human erythroid cells. Interestingly, we observed a prominent accumulation of lysine succinylation during human erythroid differentiation, sugg...

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